Services for the Hard of Hearing
Ototoxic Drugs
Albuquerque Chapter
HLAA Abq
The following list contains drugs that can have a temporary or permanent
effect on hearing such as hearing loss or tinnitus.  They were identified through the reading of Dr. Susan Kunkel from the Poison Center at the University of New Mexico College  of Pharmacy where she is a Toxicology Fellow.

.  Please note that this is not an all-inclusive list of every ototoxic drug
nor an exhaustive list of all drugs in each category.  The few
that are especially important are displayed in bold.

Some drugs have more than one use and/or may fit into more than one
category. Certain non-drug substances (e.g., various metals, chemicals and asphyxiant gases) as well as noise have been associated with hearing loss.

In some cases, the medications listed can cause hearing changes even at
regular doses. Nonetheless higher-than-recommended doses are never
a good idea and this practice would certainly increase risk of changes in
hearing. Users of these (or any other drugs) are advised to not exceed recommended dosages and to ask your doctor or pharmacist specifically
if there are any potential ototoxic effects associated with any new drug
or over-the-counter medication you are told to take.

More recent data is available at this location:
http://www.hearinglosshelp.com/articles.htm#ototoxic_drugs

NOTE: Anyone reviewing this list of ototoxic drugs is strongly
            advised NOT to discontinue taking any prescribed medication
     without first contacting the prescribing physician.

Ototoxic Drugs by Category, with Examples

Anti-infectives

Aminoglycosides (amikacin, gentamicin, tobramycin…)
Amphotericin B
Ampicillin
Antihelminthics (Praziquantel, thiabendazole)  
Chloramphenicol
Chlorhexidine (for topical use)
Chloroquine
Colistin
Griseofulvin (antifungal)
Macrolides (azithromycin, erythromycin)
Metronidazole
Nalidixic acid
Sulfonamides
Tetracyclines (Minocycline, tetracycline)
Thiabenzazole (antihelmintic)
Vancomycin

Anti-inflammatory agents  (NSAIDs, salicylates)
Aspirin (salicylic acid)
Ibuprofen
Naproxen
Fenoprofen
Indomethacin
Ketoprofen
Piroxicam
Sulindac

Antineoplastic agents
Bleomycin
Cisplatin
Cytarabine
Mechlorethamine
Methotrexate (also for RA)
Nitrogen mustard
Vinblastine
Vincristine

Cardiovascular agents
Enalapril
Captopril
Digitalis
Guanethidine
Guanfacine
Metroprolol
Minoxidil (also for alopecia)
Quinidine
Tocainide

Diuretics
Acetazolamide
Bumetanide
Ethacrynic acid
Furosemide
Mannitol

Tricyclic antidepressants
Amitriptyline
Amoxapine
Desipramine
Doxepin
Imipramine
Nortriptyline

Substances with abuse potential
Alcohol
Caffeine
Cocaine
Nicotine
Phencyclidine (PCP)

Miscellaneous agents
Albuterol
Antihistamines
Atropine
Bromates
Carbamazepine (anticonvulsant)
Haloperidol
Hydroquinone (antipigmentation agent)
Lithium
Local anesthetics (Bupivacaine, lidocaine, mepivacaine)
Metal chelators (Deferoxamine, penicillamine)
Methylphenidate
Oral contraceptives
Pentobarbital
Quinine
Theophylline



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